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Maguard™ I-100
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Iodopropynyl Butylcarbamate (IPBC)
Preservative for Personal Care Products
 
 

MAGUARD I-100 is characterized as a 100% active 3-Iodo-2-Propynyl Butyl Carbamate (IPBC). MAGUARD I-100 is a versatile and cost effective preservative that provides a high level of antimicrobial activity. It is remarkably effective in inhibiting the growth of yeasts and molds. Functional at low concentration, I-100 is fully compatible with surfactants, emulsifiers and proteins, and is stable over wide pH and temperature ranges.

IPBC preservatives have a strong safety history based on comprehensive toxicology results and significant use experience. Toxicology studies performed over the years rate IPBC as one of the safest preservatives available today. IPBC has been tested extensively to meet personal care regulatory standards in the key global regions.

Soluble in water based surfactants and oil phase ingredients in emulsions, use MAGUARD I-100 to preserve Shampoos, Conditioners, Personal Scrubbing and Cleansing Wipes, Creams and Lotions, Sun Screens, Makeup and Powders with confidence.

INCI Name: Iodopropynyl Butylcarbamate, CAS#: 55406-53-6
Typical Properties
Physical form White, crystalline solid
Actives content >99 wt%
Melting Point 65-68°C
Solubility @25°C:  
  Water 0.015 wt%
  Propylene glycol 20 wt%
  Ethanol 30 wt%
  Acetone 100 wt%
Flash point None
Storage Store between 0°C(32°F) and 32°C(90°F)

Handling Information

Refer to the Material Safety Data Sheet (MSDS) available from Mason Chemical Company for information on the safe use, handling and disposal of this product.

MAGUARD I-100 is a versatile and cost effective preservative that provides a high level of antimicrobial activity. It is remarkably effective in inhibiting the growth of yeasts and molds. Functional at low concentration, I-100 is fully compatible with surfactants, emulsifiers and proteins, and is stable over wide pH and temperature ranges. Used as a Preservative in Personal Care Products, MAGUARD I-100 offers efficacy advantages over common Personal Care preservatives as the tables below illustrate:

 
EFFICACY DATA – MINIMUM INHIBITORY CONCENTRATION
Minimum Inhibitory Concentration (MIC)/ppm active
Microorganism
Maguard I-100
Typical Paraben mix
5
≥ 130
Saccharomyces cervesiae
10
≥ 200
Aspergillus niger
39
≥ 130
Candida albicans
≤ 50
≥ 130
Aureobasidium pullans
≤ 50
≥ 130
Penicillium fusiculosum
≤ 50
≥ 130
Most other fungal species
100
≥ 400
Escherichia coli
156
≥ 400
Staphylococcus aureus
625
≥ 625
Pseudomonas aeruginosa


EFFICACY DATA – PRESERVATIVE CHALLENGE TEST

Anionic Shampoo Sample w/addition of Preservative

Challenge Data – Colony Forming Units per Gram (cfu/g) Mixed Fungi (A. niger & C. albicans)

Day 0
Day 7
Day 14
Day 21
Day 28
0.0025% Maguard I-100 (25ppm active)
1-3x10 5
< 10
< 10
< 10
< 10
0.0015% Maguard I-100 (15ppm active)
1-3x10 5
3x10 2
<10
<10
<10
0.6% Typical Paraben mix (6,000ppm active)
1-3x10 5
6x10 3
4x10 3
1x10 4
2x10 4
 
Regulatory Information
North America
IPBC can be used up to 0.1% of the formulation in both rinse-off and leave-on products. There are no other restrictions or label phrase requirements. Besides the 0.1% dosage level, CIR also stated that IPBC should not be used in formulations intended to be aerosolized.
Europe & China
IPBC was moved from the “provisionally allowed preservatives” category to the “allowed preservatives” category in Annex VI, part 1 to Council Directive 76/768/EEC in early 2000 following the SCCNFP review and positive opinion 3. It can be used up to 0.05% of the formulation in both rinse-off and leave-on products. Additionally, between 0.02% and 0.05% in leave-on formulations, the product label must contain the phrase “contains iodine”. If under 0.02% IPBC, there are no label phrase requirements for leave-on products. IPBC cannot be used in oral hygiene or lip care products.
Japan
Currently, IPBC cannot be used in cosmetics though it can and has been used in household and industrial products for many years. Registration process for inclusion in the Japanese positive list of allowed preservatives is ongoing.

Refer to Material Safety Data Sheet for Handling and Safety Information and Toxicology Summary.
 
 
 
 
 
 
 
 
 
 
 
 
 
 
       
  PL/MC V.093004    
 
 
 
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